Remarkably, few studies have been done to compare trace metal profiles between diseased and healthy states for tissues and body fluids in the organism. Thus for example, data for metal profiles on healthy tissue vs. diseased tissue from the same subject are unavailable, yet such data might be useful in developing a better understanding of the diseased state. Further, for those metals with marked differences between healthy and diseased states, doing studies to establish the differences or similarities in metal species could provide key evidence regarding molecular level information about the two states. Similar studies are necessary for body fluids as well and ultimately yield great insights to the molecular level phenomena associated with the disease.