Often trace level analyses for phosphorous containing compounds utilize radioactive methods. With state-of-the-art technologies, it is now possible to analyze these compounds, from low to high molecular weights, in such diverse categories such as pesticides, herbicides, fire retardants, warfare agents through phosphorylated proteins or phosphopeptides. We have used collision/reaction cell ICPMS to determine a number of these compound types utilizing ³¹P, the only natural phosphorous isotope. These methods have given detection levels appreciably superior to those current competitive methods and have the great advantage of not requiring radioactive isotopes. For example a relatively new study involving VX and Sarin warfare agent hydrolyzates show detection capabilities at least 100 x lower than other current methods. Future studies will expand the list of agents and expand the technique through various other chromatographic types. (See publications and presentations).