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Career summary
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8
years of research experience in chemistry, resulting 15 publications, 6 presentations
and 2 patents. Specializing in
investigation of metabolites and proteins in biological systems using
GC/LC/MS, with rich experiences in polymer/organic synthesis, microchip
fabrication, and their applications in peptide delivery, immunoassays and
liquid crystals.
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Education
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2006-2010
(expected)
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Ph.D,
Analytical Chemistry
University of Cincinnati, OH
Dissertation:
Investigation of biologically important metals/metalloids using multiple techniques
of chromatography and mass spectrometry
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2003-2006
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MS,
Polymer Chemistry & Physics
Nankai University, Tianjin, CHINA
Thesis:
Synthesis and characterization of
polymeric peptide/protein vectors and cholesteric liquid crystals
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1999-2003
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BS,
Chemistry
Nankai
University, Tianjin, CHINA
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Research Experience
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2008-present
Cincinnati
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Developing a novel method for quantification and identification of metal-binding
compounds/proteins in macrophage cells of mice and pathogens using
multi-dimensional HPLC-ICP-MS, ESI-MS and MALDI-TOF-MS.
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2009-present
Cincinnati
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Looking for selenium-containing proteins in selenium-enriched soybean:
De novo elemental-specific peptide sequencing.
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2007-09
Cincinnati
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Studied selenium metabolites in selenium-enriched soybean using
SEC/IEC/IP-RP-HPLC with ICP-MS/ESI-MS detection.
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2007-09
Cincinnati
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Developed a quantitative and qualitative method for selenium
speciation in selenium-enriched kale utilizing both atomic and molecular
mass spectrometry
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2007-present
Cincinnati
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Developing a method for quantitative and qualitative analysis of selenium
volatiles produced by genetically modified plants via solid phase
micro-extraction (SPME) using GC-ICP-MS and GC-TOF-MS
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2003-06
Tianjin
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Designed and synthesized a series of novel cholesteric liquid
crystals. Their confirmation changes were observed under varying electric
fields and temperatures. Their properties of display were evaluated as
well.
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2003-06
Tianjin
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Applied soft-lithography and micro-contact printing techniques in surface
modification on PDMS, mica and glass. They were also used for fabricating
microchips.
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2005-06
Tianjin
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Synthesized bio-compatible polymers for grafting peptides/proteins
using atomic transfer radical polymerization (ATRP).
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2002-03
Tianjin
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Synthesized and evaluated a polymeric absorbent of low density
lipoproteins using suspension polymerization
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Instrumental skills
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HPLC
4
yrs
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Agilent
1100 (conventional flow)/1200 (capillary and nano flow)
Ion
exchange, reversed phase, size-exclusion, normal phase
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GC
4
yrs
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Agilent
6890 coupled with ICP-MS/TOF-MS
SPME
headspace analysis, trace elemental analysis in liquid
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ICP-MS
4
yrs
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Agilent
7500/7700
Total
elemental analysis, on-line detection with GC/LC, isotopic dilution
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ESI-MS
4
yrs
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Agilent
6340 HPLC-Chip/Trap XCT Ultra
Metabolite
identification, peptide sequencing, database searching
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NMR
2
yrs
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Varian
Utility plus-400
1H
NMR of synthesized polymer and organic compounds
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FT-IR
2
yrs
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Bio-Rad
FTS 135 FT-IR
IR
of organic compounds
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DSC
2
yrs
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Netzsch
DSC 204
DSC
analysis of synthesized liquid crystal compounds
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Publications
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 1.
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Qilin Chan, Scott E. Afton, Joseph A. Caruso. Investigation of selenium metabolites in
Se-enriched kale, Brassica oleracea A, via HPLC-ICPMS and nanoESI-ITMS. 2009. (submitted)
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2.
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Qilin Chan, Scott E. Afton, Joseph A. Caruso. Selenium speciation profiles in
selenite-enriched soybean (Glycine Max) by HPLC-ICPMS and ESI-ITMS.
2009. (submitted)
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3.
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Katarzyna Wrobel, Crescencio Rodríguez Flores, Qilin Chan, Kazimierz Wrobel. Ribonucleoside labeling with Os(VI)-a
methodological approach to evaluation of RNA methylation by HPLC-ICP-MS.
2009. (submitted)
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4.
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Yong Fang, Yaofang Zhang, Brittany Catron, Qilin Chan, Qiuhui Hu and
Joseph A. Caruso. Identification of Se compounds in regular rice
and Se-enriched rice by foliar
application: HPLC-ICPMS and Nano-ESI-ITMS for detection. JAAS, 2009. (accepted)
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5.
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Renee N. Easter, Qilin Chan,
Barry Lai, Eric L. Ritman, Joseph A. Caruso, Zhenyu Qin. Vascular metallomics: copper in the
vasculature. Vascular Medicine, 2009. (accepted)
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6.
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Michael
S. Winters, Daniel S. Spellman, Qilin Chan, Francisco J Gomez, Margarita Hernandez, Brittany Catron, Alan G
Smulian, Thomas A Neubert and George S Deepe Jr. Histoplasma capsulatum proteome response to decreased iron
availability. Proteome
Science, 2008, 6, 36.
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7.
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Sen Hou, Xizeng Feng, Likai Wang,
Qilin Chan. Microcontact printing of multiproteins on the GA modified
glass substrate and its application in the research of immunoassays. Solid
State Phenomena, 2007, 121-123, 721.
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8.
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Yanlian
Yang, Qilin Chan, Xiaojing Ma,
Ke Deng, Yongtao Shen, Xizeng Feng, Chen Wang. Electrical conformational bistability of dimesogen molecules with a
molecular chord structure. Angewandte Chemie International
Edition，2006, 45,
6889.
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9.
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Likai
Wang, Xizeng Feng, Sen Hou, Qilin
Chan, Ming Qin. Microcontact
printing of multiproteins on the modified mica substrate and the research
of immunoassays. Surface
and Interface Analysis, 2006, 38, 44.
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10.
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Yongtao Shen,
Yang
Yao,
Qilin
Chan,
Xizeng Feng. Comparative research of
supermolecular self-assemble dimesogenic cholesteric liquid crystals.
Chinese Journal of Liquid Crystals and Displays, 2005, 21, 599.
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11.
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Qilin Chan, Xizeng Feng, Yongtao Shen, Xiao Peng. Study of preparation and properties of
novel dimesogenic cholesteric liquid crystalline with long flexible
spacers. Chinese Journal of
Liquid Crystals and Displays, 2005,
20, 5, 361-364.
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12.
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Yongtao Shen, Xizeng Feng, Qilin Chan, Xiao Peng. Supramolecular
liquid crystalline architechtures by hierarchical self‐assembly. Chemical Journal on
Internet, 2005, 7, 30.
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13.
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Qilin Chan, Xizeng Feng. Cholesteric liquid
crystals application in color display technology.
Advanced Display, 2004, 5, 17.
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14.
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Xizeng Feng, Sen Hou, Qilin Chan, Likai Wang.
Microcontact printing techniques in bioscience. Chem. Res. Chinese Univ.,
2004, 20, 826.
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15.
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Xizeng Feng, Sen Hou, Likai Wang, Qilin Chan, Peidong Han.
Microfluidic networks techniques in biosciences. Chemical Journal on
Internet, 2004, 6, 62.
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Presentations
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1.
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Kristopher
Wright, Qilin Chan and Joseph A. Caruso. Monitoring environmental contamination
via measuring metals in lichens using ICPMS. NSF-REU Poster Session, Cincinnati, OH, August 2009. (Poster)
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2.
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Qilin Chan, Scott E. Afton and Joseph A. Caruso. Characterization of selenium metabolites
in Se-enriched kale (Brissica oleracea) via ion-pairing reversed phase
chromatography with ICPMS and ESI-IT-MS detection, ASMS Conference on Mass Spectrometry,
Philadelphia, PA, June 2009. (Oral)
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3.
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Qilin Chan, Scott E. Afton and Joseph A. Caruso. The investigation of selenium metabolites
in soybean (Glycine Max) via ion-pairing reversed phase chromatography with
ICPMS and ESI-IT-MS, International
Symposium on Metallomics, Cincinnati, OH, June 2009. (Oral)
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4.
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Michael
S. Winters, Qilin Chan, Joseph
A. Caruso and George S. Deepe. Zn
limitation as a host defense mechanism against Histoplasma capsulatum,
International Symposium on
Metallomics, Cincinnati, OH, June 2009.
(Poster)
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5.
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Qilin Chan, Scott E. Afton, Joseph A. Caruso. The investigation of selenium metabolites
in kale (Brassica oleracea acephala) utilizing HPLC with ICPMS
detection, 40th Central Regional
Meeting of the American Chemical Society (CERMACS), Columbus, OH, June 2008. (Poster)
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6.
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Qilin Chan, Scott E. Afton, Joseph A. Caruso. The investigation of selenium metabolites
in kale utilizing HPLC-ICPMS and HPLC-ESI-MS, Winter Conference on
Plasma Spectrochemistry, Temecula, CA, January 2008. (Poster)
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Patents
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Work Experience
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 2006-present
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Teaching
assistant, Department of Chemistry, University of
Cincinnati
Taught
laboratories of Freshmen Chemistry/General, Organic and Biochemistry
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2009.summer
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Research
assistant, Department of Chemistry, University of
Cincinnati
Measured
total metal quantity in lichens using ICP-MS with an
undergraduate
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2002-2003
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Research
assistant, College of Chemistry, Nankai University,
CHINA
Synthesized
and evaluated a polymeric absorbent for low density lipoprotein
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References
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Dr. Joseph A.
Caruso
Department of Chemistry
University of Cincinnati
Cincinnati, OH 45221
(513)556‐9306
joseph.caruso@uc.edu
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Dr.
Michael S. Winters
Division of Infectious Diseases
University of Cincinnati College of Medicine
Cincinnati, OH 45267
(513)558-4704
winterms@ucmail.uc.edu
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