Planning
Chair
Alison A. Weiss
The Weiss lab focuses on host-pathogen interactions with regard to infectious diarrhea. We have employed a new experimental model to study enteric pathogens, pluripotent stem cell “induced human intestinal organoids” (iHIOs). These “mini-guts” faithfully represent differentiated human intestinal tissue. We have successfully used iHIOs to model human intestinal responses to bacterial infection and toxins, including E. coli O157:H7, Shiga toxin, C. difficile toxins, and microcystin (blue-green algae toxin).
Recently we have extended these studies to examine intestinal toxicity due to cytotoxic chemotherapy. An estimated 16% of cancer and transplant patients receiving chemotherapy develop bloodstream infections due to mucosal barrier injury, despite almost universal use of antibiotic prophylaxis. Toxigenic C. difficile infection is also common. We are using human intestinal organoids to examine the interplay between the host intestinal tract and the human microbiome following cytotoxic chemotherapy treatment.
Recently we have extended these studies to examine intestinal toxicity due to cytotoxic chemotherapy. An estimated 16% of cancer and transplant patients receiving chemotherapy develop bloodstream infections due to mucosal barrier injury, despite almost universal use of antibiotic prophylaxis. Toxigenic C. difficile infection is also common. We are using human intestinal organoids to examine the interplay between the host intestinal tract and the human microbiome following cytotoxic chemotherapy treatment.
Description of Committee
The charge of the Planning Committee is to consider all aspects of planning, both curricular and physical, and make recommendations concerning the development of short-range, intermediate-range, and long-range plans. In addition, the committee shall examine, review and make recommendations about proposals initiated by the University administration or other parties.
| Name | Term | |
|---|---|---|
| Rebecka Lindau (Libraries) | 2021-23 | lindaura@ucmail.uc.edu |
| Christine Tonnis (ELCE) | 2021-23 | tonniscm@ucmail.uc.edu |
| Tasha Turner-Bicknell (CoN) | 2021-23 | turnerta@ucmail.uc.edu |
| Adrienne Davis-Zapfe (CAHS) | 2022-24 | davia8@ucmail.uc.edu |
| Rob Rude (Clermont) | 2022-24 | rob.rude@uc.edu |
| Matthew Tibbs (CCM) | 2022-24 | tibbsmd@ucmail.uc.edu |
Responsibilities
- Review and make recommendations on all manner of development, curricular and physical
- Examine and make recommendations about such proposals initiated by University administration
Membership
- 6 total elected members
- Members elected to serve two year term
- Terms will be staggered, 3 elected in odd years; 3 elected in even years