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Behavior Core Services
Get advice for behavioral assays to test your specific hypotheses. Expand
Contact the MMPC for specific questions, advice and help with experimental design..
C1106 - Telemetry - Cardiac parameters Expand
Used to continuously measure heart rate, blood pressure, and home cage locomotor activity from undisturbed mice over long periods of time, thereby avoiding the confounds of handling stress.
C1117 -Feeding & weighing food intake Expand
Used for obesity and diabetes studies, as well as testing various feeding paradigms (e.g., macronutrient selection, binge eating).
C1118 -Food preference tests Expand
Used to measure reward value, sensitivity and taste preferences.
Automated metabolic caging system to assess food and water intake, locomotor activity, and metabolic rate (oxygen consumption and CO2 production).
C1120-Running wheel cages Expand
Used for obesity, metabolism, exercise and motor ability studies.
C1121-Operant fixed ratio Expand
Used to measure of basic cognition/learning.
C1122-Operant progressive ratio Expand
Used to measure motivation to obtain food reward.
C1123-5-choice serial reaction time trial Expand
Used to assess executive function (attention and impulsivity).
C1124-Delayed discounting Expand
Used to assess impulsive choice.
C1125-Social learning of food stimuli Expand
Used in social interaction tests of reward and nutrient leaving.
C1126-Conditioned taste aversion Expand
Used to assess the negative effects of pharmacological agents. Often a choice test for initial preclinical testing, and a test of amygdala function.
C1127-Conditioned place preference Expand
Used to assess the rewarding properties of a stimulus and reward learning.
C1128-Radial arm maze Expand
Used to assess spatial and non-spatial learning. Sensitive measure of hippocampal function. Can be used to distinguish between working (short term) and reference (long term memory).
C1129-Morris water maze Expand
Classic test to assess spatial and non-spatial learning. Sensitive measure of hippocampal function.
C1130-Hole-board maze Expand
Used to assess learning, memory and stimulus discrimination.
C1131-Novel object recognition test Expand
Used to assess working memory (prefrontal cortex and hippocampal function).
C1132-Acute stress challenge Expand
Used to assess the effects of acute stress exposure on energy balance, metabolism and behavior.
C1133-Chronic variable stress challenge Expand
Used to assess the effects of long-term exposure to stress on energy balance, metabolism and behavior.
C1134- Collecting post-stress plasma samples Expand
Used to measure hormonal (e.g., ACTH, corticosterone, insulin) and metabolite (e.g., glucose, fatty acid) responses to stress.
C1135- Active and passive avoidance Expand
Measures fear learning and long-term memory.
C1136- Elevated plus maze Expand
Used to assess anxiety-related behavior.
C1137- Open field test Expand
Used to assess anxiety-related behavior and/or general locomotor ability.
C1138- Forced swim test Expand
Used to assess depressive-like behavior.
C1139- Tail suspension test Expand
Used to assess depressive-like behavior.
C1140- Sucrose preference test Expand
Used to assess taste discrimination, anhedonia (a depressive-like behavior), and reward-related phenotypes.
C1145- Implantation of Indwelling Brain Cannulation Expand
Adult mice will be anesthetized and secured in a stereotaxic instrument. An appropriate sized brain cannula will be implanted into the brain area of interest and secured using glue and dental acrylic. Once acrylic is dried a dummy is screwed onto the cannula. The cannula placement will allow experimental compound administration to a specific brain region. Animals will recover to pre-surgical body weight (aprox. 3-7 days) before experimental compound is administered.
C1146- Administration of Experimental Compounds Expand
Animals will be administered an experimental compound via the appropriate route (eg: IP, SQ, IM, Brain infusion, oral gavage). This charge will also include preparing compounds into working solutions.