Hoxworth Blood Center's Research Division shines with 2023 national and international publications

A milestone year in transfusion medicine

Hoxworth Blood Center, University of Cincinnati, serves as the sole blood provider for over 30 hospitals in 18 counties, and is the oldest blood center in the nation. In addition to its vital roles in blood banking and transplant medicine for Tri-State local hospitals, Hoxworth is the home for world-renowned researchers and groundbreaking innovations.

Since its beginning in 1938 under the leadership of Dr. Paul I. Hoxworth, Hoxworth Blood Center has been dedicated to advancing the hemotherapy field. All Hoxworth divisions aim to bridge fundamental research with clinical care. Hoxworth is committed to enhancing the quality, safety and effectiveness of the blood and hematopoietic cell therapies. Hoxworth research includes clinical research, basic biological research and translational transfusion medicine and transplant research.

Hoxworth faculty and staff have published in many prestigious, peer-reviewed, national and international journals. In 2023, Hoxworth Blood Center made notable contributions to the field. Hoxworth authors are bolded below.

  • Singh AK, Prasad P, Cancelas JA. Mesenchymal stromal cells, metabolism, and mitochondrial transfer in bone marrow normal and malignant hematopoiesis. Frontiers in Cell and Developmental Biology. 2023;11.
  • Vandenbroeke T, Gloor C, Wingfield T, Leite C, Carr K, Turner C, Ngamsuntikul S, Sutor L, Compton F, Nestheide S, Rugg N, Cancelas JA, Dumont LJ. In vitro quality parameters of whole blood‐derived platelets pooled using two different platelet pooling sets and stored up to 7 days are similar. Transfusion. 2024 Jan;64(1):132-40.
  • Solomon M, Song B, Govindarajah V, Good S, Arasu A, Hinton EB, Thakkar K, Bartram J, Filippi MD, Cancelas JA, Salomonis N. Slow cycling and durable Flt3+ progenitors contribute to hematopoiesis under native conditions. Journal of Experimental Medicine. 2023 Nov 1;221(1):e20231035.
  • Sarkar A, Niraula G, LeVine D, Zhao Y, Tu Y, Mollaeian K, Ren J, Que L, Wang X. Development of a Ratiometric Tension Sensor Exclusively Responding to Integrin Tension Magnitude in Live Cells. ACS Sensors. 2023 Sep 22;8(10):3701-12.
  • Thant M, Cancelas J, Kaplan A. The enhanced direct antiglobulin test in current practice has a limited impact on management of adult patients. Transfusion and Apheresis Science. 2023 Oct 1;62(5):103768.
  • Qian F, Nettleford SK, Zhou J, Arner BE, Hall MA, Sharma A, Annageldiyev C, Rossi RM, Tukaramrao DB, Sarkar D, Hegde S. Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells. Cell Reports. 2023 Jul 25;42(7).
  • Dandamudi A, Seibel W, Tourdot B, Cancelas JA, Akbar H, Zheng Y. Structure–Activity Relationship Analysis of Rhosin, a RhoA GTPase Inhibitor, Reveals a New Class of Antiplatelet Agents. International Journal of Molecular Sciences. 2023 Feb 19;24(4):4167.
  • Dandamudi A, Akbar H, Cancelas J, Zheng Y. Rho GTPase Signaling in Platelet Regulation and Implication for Antiplatelet Therapies. International Journal of Molecular Sciences. 2023 Jan 28;24(3):2519.
  • Galletta TJ, Lane A, Lutzko C, Leemhuis T, Cancelas JA, Khoury R, Wang YM, Hanley PJ, Keller MD, Bollard CM, Davies SM. Third-party and patient-specific donor-derived virus-specific T cells demonstrate similar efficacy and safety for management of viral infections after hematopoietic stem cell transplantation in children and young adults. Transplantation and Cellular Therapy. 2023 May 1;29(5):305-10.
  • Menéndez-Gutiérrez MP, Porcuna J, Nayak R, Paredes A, Niu H, Núñez V, Paranjpe A, Gómez MJ, Bhattacharjee A, Schnell DJ, Sánchez-Cabo F. Retinoid X receptor promotes hematopoietic stem cell fitness and quiescence and preserves hematopoietic homeostasis. Blood. 2023 Feb 9;141(6):592-608.
  • Salazar RD, Weidner KR, Alquist CR. Therapeutic plasma exchange in refractory Susac's syndrome: A brief report. Journal of Clinical Apheresis. 2024 Feb 1.
  • Connelly‐Smith L, Alquist CR, Aqui NA, Hofmann JC, Klingel R, Onwuemene OA, Patriquin CJ, Pham HP, Sanchez AP, Schneiderman J, Witt V. Guidelines on the Use of therapeutic apheresis in clinical practice–Evidence‐Based approach from the Writing Committee of the American Society for Apheresis: The Ninth Special Issue. Journal of Clinical Apheresis. 2023 Apr;38(2):77-278.
  • C Alquist and HC Sullivan. Chapter 18: Laboratory Management. In: HC Sullivan ed. Transfusion Medicine Self-Assessment and Review, 4th ed. AABB. Bethesda, MD: October 2023. Developed to be used with the Technical Manual, this popular resource helps trainees learn and review concepts in an examination format. This edition contains 900 brand-new multiple-choice questions covering 18 topics in blood collection/transfusion and biotherapies.
  • Alquist C, Greenspan N, Wald D. Chapter 5: HLA Molecular Basis, Typing, and Matching. In: Cancelas J, Bandarenko, N, eds. Cellular Therapy: A Handbook. 2nd ed. Bethesda, MD: AABB, September 2023:91-112.
  • Ipe TS and Alquist CR. Chapter 17: Transfusion-Service-Related Activities: Pretransfusion Testing and Storage, Monitoring, Processing, Distribution, and Inventory Management of Blood Components. In: Delaney M and Cohn CS (eds.) The Technical Manual, 21st ed. Bethesda, MD: AABB, August 2023. 70 yr anniversary edition of AABB’s most popular book, a must-have resource for health care professionals and students working in blood banking and transfusion medicine throughout the world. Adopted by all branches of the United States Armed Services as their official manuals for blood banking and transfusion medicine activities.

Learn more about Hoxworth Blood Center’s research faculty and division. 

Featured photo at top of donated blood. Photo/University of Cincinnati.

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