UC research featured as cover story of neuroscience journal

The cover of the March 2022 volume of the Journal of Neuroscience may at first glance look like a piece of pointillism artwork. Its brilliant colors of magenta, blue and green grabbed the eyes of the journal's editors, who decided to put it on the front page.

June Goto, PhD, assistant professor with the division of pediatric neurosurgery in the University of Cincinnati's College of Medicine and the study's main author, describes what the image actually is.

"This is a beautiful picture of a normal-looking brain before the onset of hydrocephalus," Goto says. "The colors indicate the different layers of cortical cerebral cortex."

The chosen image shows a section of the brain from a mouse 18 days after fertilization (E18). At this point, the mouse's cortical layers are well retained, but will start to thin after its birth.

Goto and Francesco Mangano, DO, professor and Mary Jane and Bob Tritsch Chair of Pediatric Neurosurgery and also one of the study's authors, picked several images for submission to the journal, but ultimately decided on the featured image.

"It was very surprising," Goto says of her first cover article.

cover featuring brain image

Journal of Neuroscience Features CCHMC Research on Cover. Courtesy of Journal of Neuroscience.

The study itself looked at the effect of anti-inflammatory drug treatment on a neonatal hydrocephalus model. Although it did not largely improve the ventricular site, it did significantly improve the neuronal cell development.

"It was a great surprise for us because it had such drastic functional and developmental effect," said Goto, "even though you don't see much improvement in the anatomy itself."

The results of this study excite Goto, who says this published article is just the beginning.

"I'd like to address whether using anti-inflammatory drugs can actually improve the neurological symptoms of hydrocephalus," she said. 

Goto will investigate that next and hopes to publish the results within two years. 

Featured photo at top courtesy of the Journal of Neuroscience.

Related Stories


Local 12: UC startup gains approval for trials

May 30, 2023

A startup founded by four University of Cincinnati physicians gained FDA approval to move forward with clinical trials for its portable system that can detect brain injuries, Local 12 reported.


Newsweek: Conservative justices deal a blow to Ivermectin in...

May 29, 2023

The Wisconsin Supreme Court ruled earlier this month that hospitals can’t be forced to issue Ivermectin to patients. It backed an earlier appeals court decision. Jennifer Bard, PhD, professor at the University of Cincinnati College of Law, weighed in on the decision during an interview with Newsweek.


Study finds distinct patterns of preexisting brain health...

May 26, 2023

The University of Cincinnati's Achala Vagal presented the results of the first large-scale assessment of radiological brain health in stroke patients in a population at the European Stroke Organization Conference 2023 in Munich, Germany.

Debug Query for this