UC's custom 3D-printed skull implants go global
December 13, 2019
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Radiologists at the University of Cincinnati are offering a clinical trial comparing the two types of digital mammography available for breast cancer screening.
The randomized study, led locally by Lawrence Sobel, MD, assistant professor in the Department of Radiology at the UC College of Medicine and director of breast imaging for UC Health, will compare the use of 2D images to 3D images, known as tomosynthesis to determine that 3D tomosynthesis is more effective in the diagnosis of breast cancers.
“We are enrolling healthy women, ages 45 to 74, who are already planning to get routine mammograms,” Sobel says. “By taking part in the trial, the 165,000 planned participants nationally will provide critical information that will help researchers learn how to most effectively screen women for breast cancer and help women make informed decisions about screening tests in the future. This is the first, randomized trial to compare these two types of mammography; this study aims to confirm that 3D technology reduces a woman’s risk of developing an advanced cancer in comparison to 2D.”
Researchers are collecting data on the results of every mammogram, whether the imaging shows no sign of cancer, suspicious areas or a breast cancer, and medical follow-up, such as additional imaging or biopsies, is also being reported. Researchers involved in the study intend to follow all participants for breast cancer status, treatment and outcomes until the end of the study (at least until 2025). Most women enrolled in the trial undergo annual screening, but postmenopausal women with no high-risk factors will be screened every two years.
Sobel adds that researchers are also analyzing tissue collected from women who have biopsies during the trial, which will help in learning more about the biology of breast cancers detected through screening.
“In addition, the trial is building a biorepository for future research on genetic markers for breast cancer by asking all participants to voluntarily submit blood samples and swabs of cells from inside the mouth,” he says. “This data could, in the future, help women and their doctors decide the best ways to screen for breast cancer by evaluating their individual risk factors for developing the disease.
“We hope this trial will provide new insights into the way we screen for breast cancer to provide better outcomes for patients and prevent the disease in its earliest stages.”
*Photo of 3D mammography machine above/Credit: Colleen Kelley
Eligible women who are patients at UC Health and are due for a mammogram will be contacted shortly before their scheduled screening study to discuss possible enrollment. For more information, call 513-584-3135.
December 13, 2019
December 12, 2019
Angela Clark and her research team started noticing an unprecedented trend — an increasing number of people who needed emergency services after receiving naloxone (Narcan), an opioid antagonist used for complete or partial reversal of opioid overdose. The overdose victims were arriving outside the emergency department, which meant nurses were walking outside the emergency department to aid these incapacitated patients. Clark knew nurses had not been trained to respond to these situations, and their safety was at risk. Angela Clark, a professor of nursing at the University of Cincinnati, decided to develop a training program to teach nurses how to protect themselves while leveraging their medical expertise. “Nurses are trained to put the patient first, while police are trained to put safety first,” said Clark, whose team launched the Be-SAFE program in 2017.
December 11, 2019
It’s no secret that genetics, family history and ethnicity can play a role in heart disease. Sakthivel Sadayappan, a professor at the University of Cincinnati’s College of Medicine, has spent more than two decades examining that complex tie and discovering a genetic variant that predisposes people of South Asian descent to hypertrophic cardiomyopathy, commonly known as an enlarged heart. Sadayappan uses that knowledge unearthed in the laboratory to reach members of the South Asian community through a non-profit known as Red Saree.