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Drug Target Review: Could a nasal spray prevent COVID-19?

A UC study shows that a lipid might prevent infection and could potentially be easily administered

According to a study led by UC researchers, the lipid sphingosine may have the ability to inhibit SARS-CoV-2 infection and could potentially be delivered in a nasal spray to prevent COVID-19 infections.

Researchers, led by a visiting professor in the UC Department of Surgery Erich Gulbins, MD,  have examined pre-existing research into bacterial respiratory tract infections and applied the findings to COVID-19, with some success. According to the scientists, a sphingosine nasal spray could potentially prevent or treat SARS-CoV-2 infections.

“We investigated whether a specific lipid [sphingosine] is able to interfere with the binding of SARS-CoV-2 to human epithelial cells,” said Gulbins, corresponding author on the study, published in the Journal of Biological Chemistry. 

Read the full story.

Read the UC News release.

Featured photo of the lipid sphingosine courtesy of Jynto.

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