Funding helps put UC near the forefront of cancer research
Chemistry professor In-Kwon Kim advances breast cancer research through ACS grant
By Benjamin Harrison
The ongoing fight against cancer isn’t going to go away anytime soon, but work by chemists at the University of Cincinnati could lead to important advances.
In-Kwon Kim, assistant professor of chemistry in UC's College of Arts and Sciences, has received a four-year, nearly $800,000 grant from the American Cancer Society. With the help of this grant, Kim and his team hopes to put UC the head of the next-stage cancer treatment.
Kim’s research group focuses primarily on the ADP-ribosylation cycle that regulates many cellular signaling pathways, including DNA repair and cell death. Kim and his team are working with human enzymes that remove different types of ADP-ribosylations. These enzymes play key roles in DNA repair and are often associated with breast cancer.
UC College of Arts and Sciences assistant professor of Chemistry In-Kwon Kim
In the world of cancer research, it can take time for promising results. But with the help of his team and the Cancer Foundations, Kim has started to see signs that things are moving in the right direction.
“A defective DNA repair is a hallmark of cancer,” Kim said. “So far, drugs targeting the DNA repair defects have shown promise in cancer treatment. However, they also have limitations. Cancer cells frequently develop drug resistance. Our research has been focused on the development of alternatives to current cancer drugs in the market.”
Indeed, Kim and his team published a paper on selective PARG inhibitors last year in the journal Nature Communications.
Kim is leading a research group with six graduate students and also participates in teaching biochemistry courses.
“Both for cancer research and education, the most important question is how we can leverage our information to develop safer and more effective drugs to combat diseases. And this is just what we are doing with our cancer research.” said Kim.
“I believe that our efforts to develop new tumor-selective drugs will provide better therapeutic options to breast cancer patients in the future.”
Featured image at top: Aerial view of UC's uptown campus.
Related Stories
The subtle changes in hearing you should never ignore
July 24, 2026
It’s easy to dismiss changes in hearing as minor. But as The Washington Post recently reported, these symptoms could also signal a medical emergency that many people don’t recognize — known as sudden sensorineural hearing loss, a rapid decline in hearing that occurs suddenly or over a few days.
UC experts say proper produce washing is key defense against Cyclospora
July 24, 2026
Hamilton County Public Health reports confirmed cases of cyclosporiasis, as concerns persist. Cyclospora is a parasite that can cause a stomach illness lasting days — sometimes even weeks. University of Cincinnati medical experts say it is usually linked to contaminated water or food, often fresh produce.
What are the options for male birth control?
July 24, 2026
Despite major advances in contraception during the past several decades, responsibility for pregnancy prevention falls largely on women. As recently reported in Endocrinology Advisor, a new generation of male contraceptive candidates is advancing into early- and mid-stage clinical trials.