Medical News Today: Gene mutation may be a key to lung cancer treatment
Medical News Today highlighted University of Cincinnati research recently published in the journal Nature Communications that found targeting components of lipid metabolism and synthesis could lead to an effective lung cancer treatment.
The research focused on lung cancer with a mutated KRAS gene, an oncogene that works as a gas pedal to help cancer cells grow. The team found that lung cancer with the KRAS gene had a unique lipid profile and was dependent on an enzyme called FASN that is involved in fatty acid synthesis.
The researchers found that blocking FASN promoted the death of specific lung cancer cells. Pier Paolo Scaglioni, MD, corresponding author on the study, told Medical News Today there are exciting potential treatments that could come as a result of this research.
"There is a great interest in developing drugs that target the metabolisms of cancer cells. Thus, yes, there are therapeutic implications," said Scaglioni, associate director for translational research at the University of Cincinnati Cancer Center, professor and division chief of hematology oncology in the Department of Internal Medicine in UC’s College of Medicine and a UC Health physician. "We have carried out a phase I trial with a FASN inhibitor and are performing a phase II trial in lung cancer patients with the KRAS mutation.”
Read the Medical News Today article.
Read more about Scaglioni's research.
Featured photo at top of Dr. Scaglioni with a patient courtesy of UC Health.
Related Stories
CCM welcomes new film and media scoring faculty member J.R. Paredes
May 20, 2026
UC College-Conservatory of Music Dean Pete Jutras has announced the appointment of J.R. Paredes as CCM's new Assistant Professor of Film and Media Scoring. His faculty appointment officially begins on Aug. 15, 2026. Paredes is a composer, music producer and audio post-production specialist whose work spans film, television and commercial music. His credits include original scores for feature films and series distributed on platforms such as Apple TV+ and Prime Video, as well as extensive work in sound design and mixing for film and media.
6 ways starting a GLP-1 medication could affect your emotions
May 20, 2026
When patients first start taking a glucagon-like peptide-1 (GLP-1) medication, they probably expect to feel full. But they might not anticipate how it can influence their emotions. The medications act on the stomach and the brain, said Malti Vij, MD, a University of Cincinnati adjunct associate professor in the College of Medicine's Department of Internal Medicine and a diplomate of the American Board of Obesity Medicine.