Treatment options when breast cancer becomes unresponsive to chemotherapy

The University of Cincinnati's Mahmoud Charif was featured in an Everyday Health article discussing treatment options when metastatic triple-negative breast cancer (mTNBC) becomes unresponsive to chemotherapy.

Even though chemotherapy is the standard treatment for mTNBC, it’s not uncommon for these drugs to stop working eventually. 

Charif, MD, a University of Cincinnati Cancer Center member, associate professor in the UC College of Medicine and a UC Health physician, said breast cancer cells can become resistant to chemotherapy over time, making the treatment less effective. This is especially the case for mTNBC, which is typically a more aggressive form of cancer.

Treatment options when mTNBC becomes unresponsive to chemotherapy include immunotherapy, clinical trials and a class of drugs called antibody-drug conjugates (ADCs). Charif explained ADCs combine an antibody therapy and chemotherapy to work together to kill cancer cells.

Read the Everyday Health article.

Featured photo of 3D breast cancer cell courtesy of the National Cancer Institute.