Treatment options when breast cancer becomes unresponsive to chemotherapy
UC expert speaks with Everyday Health
The University of Cincinnati's Mahmoud Charif was featured in an Everyday Health article discussing treatment options when metastatic triple-negative breast cancer (mTNBC) becomes unresponsive to chemotherapy.
Even though chemotherapy is the standard treatment for mTNBC, it’s not uncommon for these drugs to stop working eventually.
Charif, MD, a University of Cincinnati Cancer Center member, associate professor in the UC College of Medicine and a UC Health physician, said breast cancer cells can become resistant to chemotherapy over time, making the treatment less effective. This is especially the case for mTNBC, which is typically a more aggressive form of cancer.
Treatment options when mTNBC becomes unresponsive to chemotherapy include immunotherapy, clinical trials and a class of drugs called antibody-drug conjugates (ADCs). Charif explained ADCs combine an antibody therapy and chemotherapy to work together to kill cancer cells.
Read the Everyday Health article.
Featured photo of 3D breast cancer cell courtesy of the National Cancer Institute.
Related Stories
Recent advances may speed time to endometriosis diagnosis
March 16, 2026
The average time to clinical diagnosis of endometriosis is nine years. Definitive diagnosis of the disease is difficult, and until recently, has relied on laparoscopic surgery. Now, as Medscape recently reported, novel clinical recommendations, advanced diagnostic tools and research into inflammation and immune responses, are bringing promise that women with endometriosis will find relief sooner and without surgery, according to experts, including Katie Burns, PhD, University of Cincinnati College of Medicine associate professor.
Position-specific helmets may not improve protection
March 16, 2026
Local 12 highlighted a new study by biomedical engineering researchers that looked at how well new football helmets protected players from impacts that can cause concussions.
UC biologist talks about 'pearmageddon'
March 16, 2026
WLWT talks to UC biologist and Department Head Theresa Culley about invasive, nonnative Callery pear trees that are spreading across Ohio forests after they were introduced by landscapers more than 50 years ago.