Diesel Exposure Model Reduces Allergy Risk Assessment Errors

Cincinnati—University of Cincinnati (UC) environmental health experts say their research improves prior methods of classifying exposure to diesel exhaust particulates that help minimize inaccuracies and better predict a child’s risk for wheezing.

Many prior air pollution studies rely heavily on what are known as proximity (distance) exposure models, which assume all subjects in a given distance from an exposure source—for example, a major interstate highway—are equally exposed.

Pat Ryan, lead author of the UC study, says that isn’t necessarily true in urban environments, where infants are exposed to a large number of pollutants, and he advocates using the so-called land-use regression model.

“Unlike proximity models,” says Ryan, “land use regression lets us consider more complex exposure factors—like elevation and the type or number of passing vehicles—in our initial assessment. This allows us to create ‘buffers’ around specific sample sites and control for factors influencing that location’s overall diesel exposure levels.” 

Specific models are needed for evaluating exposure levels in large cities to accurately determine exposure levels and identify populations at risk for high exposure to air pollutants, Ryan says.

He will present the UC team’s findings at the annual meeting of the American Academy of Allergy, Asthma and Immunology in San Diego on Feb. 26.

Ryan and his coauthors analyzed data from 622 infants enrolled in the Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS) who were identified as being at greater risk for developing allergies because at least one of their parents had allergies.

The CCAAPS, funded by the National Institute of Environmental Health Sciences, is a five-year study examining the effects of environmental particulates and certain types of traffic on childhood respiratory health and allergy development. All infants in the study had at least one parent with known allergies.

Researchers found that infants who were exposed to the highest levels of elemental carbon—a marker of diesel exposure—were more than twice as likely to wheeze compared with the infants exposed to lower levels, which was reported in the February 2007 issue of Environmental Health Perspectives.

Research has shown that diesel exhaust particles (DEP), breathable particles able to absorb and transport proteins, aggravate rhinitis (hayfever) and asthma symptoms.

“Accurate exposure classifications are imperative in studies of air pollution, and the land use regression model allows us to use our sampled measurements to predict a specific location’s  exposure level whereas proximity studies do not take sampled levels into account nor do they examine other important factors, like wind direction or elevation.”

Collaborators in the study are UC’s Grace LeMasters, PhD, principal investigator of the CCAAPS, Linda Levin, Mark Lindsey, David Bernstein, MD, James Lockey, MD, Manuel Villareal, MD and Sergey Grinshpun, PhD, as well as Pratim Biswas, PhD, and Shaohua Hu of Washington University in St. Louis and Gurjit Khurana Hershey, MD, of Cincinnati Children’s Hospital Medical Center.