UC scientist studies role of protein in skeletal muscle disorders

College of Medicine lab tackles a rare muscle disorder leading to deformities in children

A University of Cincinnati researcher has received a five-year $2.3 million grant to study the role a protein in muscles plays in the development of a rare disease. The grant is from the National Institute of Arthritis and Musculoskeletal and Skin Diseases.

The condition, called distal arthrogryposis, is a skeletal muscle disorder characterized by the presence of joint contractures, or a tightening or shortening of the joint causing a deformity, at various parts of the body, particularly in the furthest extremities, explains Sakthivel Sadayappan, PhD, professor in the UC Division of Cardiovascular Health and Disease. The condition affects one in 3,000 live births and leads to increased connective tissue formation around the joints in a way that immobilizes muscle movement leading to deformities in children.

Sakthivel Sadayappan, PhD Cardiovascular

Sakthivel Sadayappan, PhD

“I branched out of my traditional cardiac research project to include skeletal muscle,” says Sadayappan, who oversees a team of postdoctoral fellows, graduate and medical students in his College of Medicine laboratory. “The structure and functions of [the protein] have similarities but are not identical in heart and skeletal muscles.”

Currently, treatments of distal arthrogryposis diseases can range from simple procedures such an Achilles tendon release to more moderate methods such as elbow and knee surgeries. Other treatments are more involved including surgeries to lengthen limbs or correct spines.

Sadayappan says myosin binding protein-C (MyBP-C) is essential for muscle formation, function and regulation and exists in both heart and skeletal muscle. In skeletal muscle two paralogs (genes) of the myosin binding protein-C, slow skeletal (sMyBP-C) and fast skeletal (fMyBP-C) are present and they are distinct from what is seen in heart muscle. Much of Sadayappan’s previous research has looked at myosin binding protein-C in heart muscles and its role in the development of hypertrophic cardiomyopathy in heart patients.

The goal of our current research is to define the physiologic mechanisms underlining how mutations ... in animal models leads to muscle dysfunction.

Sakthivel Sadayappan, PhD

“The goal of our current research is to define the physiologic mechanisms underlining how mutations in slow skeletal myosin binding protein-C seen in animal models leads to muscle dysfunction and contractures,” says Sadayappan. “We hypothesize that the slow skeletal protein is a key regulator of striated skeletal muscle formation and function.”

Experiments will look at defining the role of myosin binding protein-C in regulating skeletal muscle function in four unique animal models. “Understanding the molecular mechanisms that underlie a reduced contractility in muscle disease should help us identify novel therapeutic targets to improve muscle function in individuals afflicted with distal arthrogryposis,” says Sadayappan.

Featured image of Sakthivel Sadayappan, PhD, in his laboratory at the UC College of Medicine. Photo by Colleen Kelley/UC Creative + Brand.

Impact Lives Here

The University of Cincinnati is leading public urban universities into a new era of innovation and impact. Our faculty, staff and students are saving lives, changing outcomes and bending the future in our city's direction. Next Lives Here.

Stay up on all UC's COVID-19 stories, read more #UCtheGood content, or take a UC virtual visit and begin picturing yourself at an institution that inspires incredible stories.

Sadayappan’s work is supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases grant 1R01AR078001-01.

Related Stories


Heat waves in the U.S. kill more people in their homes than...

July 12, 2024

Tasha Turner-Bicknell, an associate professor in the UC College of Nursing, spoke with the Cincinnati Enquirer for a story about heat-related deaths. Many people are dying within their homes during periods of excessive heat and lack of air conditioning is a factor.


Ohio board rejects medical marijuana for autism

July 12, 2024

Cleveland.com highlighted decisions from the State Medical Board of Ohio rejecting autism and female orgasmic difficulty disorder as conditions for its medical marijuana program, following testimony from experts including the University of Cincinnati's Craig Erickson.

Debug Query for this