Funding helps put UC near the forefront of cancer research
Chemistry professor In-Kwon Kim advances breast cancer research through ACS grant
By Benjamin Harrison
The ongoing fight against cancer isn’t going to go away anytime soon, but work by chemists at the University of Cincinnati could lead to important advances.
In-Kwon Kim, assistant professor of chemistry in UC's College of Arts and Sciences, has received a four-year, nearly $800,000 grant from the American Cancer Society. With the help of this grant, Kim and his team hopes to put UC the head of the next-stage cancer treatment.
Kim’s research group focuses primarily on the ADP-ribosylation cycle that regulates many cellular signaling pathways, including DNA repair and cell death. Kim and his team are working with human enzymes that remove different types of ADP-ribosylations. These enzymes play key roles in DNA repair and are often associated with breast cancer.
UC College of Arts and Sciences assistant professor of Chemistry In-Kwon Kim
In the world of cancer research, it can take time for promising results. But with the help of his team and the Cancer Foundations, Kim has started to see signs that things are moving in the right direction.
“A defective DNA repair is a hallmark of cancer,” Kim said. “So far, drugs targeting the DNA repair defects have shown promise in cancer treatment. However, they also have limitations. Cancer cells frequently develop drug resistance. Our research has been focused on the development of alternatives to current cancer drugs in the market.”
Indeed, Kim and his team published a paper on selective PARG inhibitors last year in the journal Nature Communications.
Kim is leading a research group with six graduate students and also participates in teaching biochemistry courses.
“Both for cancer research and education, the most important question is how we can leverage our information to develop safer and more effective drugs to combat diseases. And this is just what we are doing with our cancer research.” said Kim.
“I believe that our efforts to develop new tumor-selective drugs will provide better therapeutic options to breast cancer patients in the future.”
Featured image at top: Aerial view of UC's uptown campus.
Related Stories
Download the Duo Mobile App to stay connected to UC systems
February 6, 2026
Students, faculty, and staff still using SMS text messaging or phone calls to authenticate with Duo need to switch to the Duo Mobile app as soon as possible to ensure uninterrupted access to UC systems. Learn more and find instructions under “How to switch from Text/Call to Duo Push” at uc.edu/2fa.
Will AI really replace your job?
February 6, 2026
As artificial intelligence seeps into more careers, some people wonder if any jobs will become obsolete in the coming years, according to 700WLW. Jeffrey Shaffer, director of Lindner College of Business’ Applied AI Lab, spoke with 700WLW on the future of AI in the workplace.
UC teams with historic landmark to preserve the past for the future
February 6, 2026
The landscape at Cincinnati’s historic Harriet Beecher Stowe House museum has settled in for winter, under a hard coat of frost and snow. But once spring rolls around, it will show a transformation, thanks in part to the history department at UC’s College of Arts and Sciences. The Beecher Stowe House, located at 2950 Gilbert Ave., serves as a hub for the community and historians interested in the life and political activism of the famed abolitionist. Harriet Beecher Stowe wrote the groundbreaking “Uncle Tom’s Cabin” while living there, and the home was a stop for fugitive enslaved people on the Underground Railroad prior to the Civil War.