U.S. News & World Report: Metformin may help young patients with bipolar disorder avoid weight gain
U.S. News & World Report highlighted recent research led by the University of Cincinnati and Northwell Health that found the drug metformin can help prevent or reduce weight gain in youth taking medication to treat bipolar disorder.
Medications to treat bipolar disorder, known as second-generation antipsychotics (SGAs), are often effective at helping young patients’ mental health improve but can have significant side effects including elevated blood pressure and glucose, increased appetite and weight gain.
A total of 1,565 patients aged 8-19 with bipolar disorder taking SGAs were enrolled in the study. Everyone enrolled in the trial received a lifestyle intervention with recommendations for healthy eating and exercise. Half of the youth were randomized to receive the healthy lifestyle intervention and were prescribed metformin, a medication typically used for Type 2 diabetes known to also prevent weight gain.
UC’s Jeffrey Welge, PhD, said in the short-term six-month follow-up data, metformin had a modest but significant effect at preventing and in some cases reversing weight gain in the study’s patient population. The drug was also found to be safe, with some gastrointestinal distress symptoms being the only side effects reported.
“It’s not a drug you take and weight falls off of you, but it tends to reduce that out of control appetite which we think then makes it easier for patients to adhere to a healthy diet and as they lose some weight maybe also make it easier for them to engage in more exercise,” said Welge, professor in UC’s Department of Psychiatry and Behavioral Neuroscience and Department of Environmental and Public Health Sciences. “So, the lifestyle is really what’s driving good outcomes, but metformin is in some cases putting the wind at their back to help with that.”
Read the U.S. News & World Report article.
Featured illustration at top of children in silhouette walking with colorful backpacks. Photo/A-Digit/iStock.
Related Stories
From hobbyist photographer to professional educator
October 9, 2026
DAAP alum and photographer HATSUE studied communication design after a pivot in high school from a track toward veterinary school. Today, they teach photography at 1001 Colors white working as an artist and curator in Cincinnati.
UC researcher to launch national study with $2.5 million NIH grant
October 9, 2026
A University of Cincinnati researcher has received a $2.5 million National Institutes of Health grant to conduct research during the next five years. Natalie Kreitzer, MD, a University of Cincinnati College of Medicine physician-researcher, received an R01 independent research grant from the NIH's Eunice Kennedy Shriver National Institute of Child Health and Human Development. The funding will support a test program for caregivers of patients with traumatic brain injury, as reported by the Cincinnati Business Courier.
Lighting up the skyline for Blink
October 9, 2026
A team of University of Cincinnati College-Conservatory of Music students designed “Echoes of Light,” a music-and-light installation on Ohio’s largest mural for BLINK, Cincinnati’s massive public light and art festival.