So far, Steckl said, animal trials have shown that electrospun fibers provide even better results because surgeons can apply different combinations of treatments that deliver medicine for the desired duration.
“Dr. Steckl’s unique electrospun formulation was appealing to us for multiple reasons,” Tyler said. “It has the capability to slowly release its payload, it’s biocompatible and multiple drugs can be loaded and released from it.”
Tyler said they plan to apply electrospinning to other FDA-approved drugs in unique combinations for the treatment of brain tumors.
“Our hope is to deliver these agents using Dr. Steckl’s technology to ultimately increase therapeutic options for patients with brain tumors,” Tyler said.
Steckl said the large surface area and custom properties of the fibers make them an ideal drug-delivery system. For example, patients who have to take drugs multiple times per day for conditions such as Parkinson’s disease might be able to take a single long-acting dose made from electrospun medicines.
“The problem is you may remember your morning dose, but you might forget your afternoon dose,” he said. “Should I take another one? Did I take three today? A single longer-lasting dose is a lot simpler.”
Steckl said researchers are creating electrospun medicines with fibers that only dissolve at a particular acidity in the digestive system. This could delay or extend the release of the active ingredients.
“It’s a pretty clever idea,” he said.